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. 2011 Sep 6;108(38):16092–16097. doi: 10.1073/pnas.1105062108

Fig. 1.

Fig. 1.

Muscle-specific reductions in AMPK phosphorylation and subunit expression in AMPK β2 and β1β2 M-KO mice results in dramatic reductions in exercise tolerance. (A) Expression of AMPK α1, α2, β1, and β2 in extensor digitorium longus (EDL) muscle. ND, not detectable. (B) AMPK T172 phosphorylation in resting (Bas, basal) and electrically stimulated (Con, contraction) EDL and soleus muscles. (C) β1β2M-KO mice have reduced voluntary wheel activity. (D and E) Mean maximal running speed (D) and distance run (E) of β1, β2, and β1β2 M-KO and wild-type (WT) littermates during a progressive treadmill running exercise test. Data are means ± SEM, n = 8−10, *P < 0.05 compared with WT littermate. #P < 0.05 compared with basal. For protein expression, values were corrected for equal protein loading using GAPDH.