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. 2011 Sep 12;108(38):16002–16007. doi: 10.1073/pnas.1109493108

Fig. 3.

Fig. 3.

Bone marrow-derived S100A4+ stromal cells do not functionally contribute to metastatic colonization. (A) S100A4+ (green) and CD45+ (red) stromal cells in metastatic lung tissue of S100A4-GFP mice and WT mice bearing an S100A4-GFP bone marrow (BM) transplant. White arrows point to S100A4-GFP+ stromal cells; yellow arrowheads point to S100A4-GFP+/CD45+ stromal cells. (Scale bars: 20 μm.) (B) Quantification of metastatic area in WT mice transplanted with WT bone marrow (WT BM > WT, n = 13), S100A4-tk mice transplanted with S100A4-tk bone marrow (TK BM > TK, n = 13), WT mice transplanted with S100A4-tk bone marrow (TK BM > WT, n = 10), and S100A4-tk mice transplanted with WT bone marrow (WT BM > TK, n = 12). Representative H&E-stained lung sections are displayed with dotted lines encircling metastatic lesions. (Scale bars: 50 μm.) Mean ± SEM. *P < 0.05.