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5′–3′ mRNA degradation enzymes are required for ZAP-mediated viral mRNA degradation. Experiments were performed as described in the legend to Fig. 4. (A) Validation of the abilities of the shRNAs indicated to down-regulate the expression of the proteins indicated. (B) Down-regulation of Dcp1a, Dcp2, and Xrn1 reduced ZAP's activity in the degradation of nef-luc mRNA. Data presented are means ± SD from three independent experiments.
