Fig. 2.

Treatment of YF in Syrian hamsters. Survival of Syrian hamsters treated before (A) or after (C) viral inoculation. Dosing regimens are indicated and described in Materials and Methods. Serum ALT was sampled at day 6 postinfection for the group receiving squalamine before (B) or after (D) viral inoculation [treatment groups (n = 10) and D5W (5% dextrose) placebo (n = 20)]. All animals that had survived 14 d remained alive until day 21 and were designated as cured. [We should note that, in the treatment experiment (C), a cohort that received 15 mg/kg 1 d before virus inoculation (a control prevention study) achieved a 40% survival rate and has been omitted from the graph for the sake of clarity.]