Fig. 3.

Treatment of EEEV in Syrian hamsters. Survival (A) and average body weight (B) of Syrian hamsters infected with EEEV and treated s.c. with either squalamine (10 mg/kg) or placebo (D5W) on days −1 to 6 after infection. (C) Viremia of Syrian hamsters on days 1–4 after infection with EEEV that were treated with either squalamine or placebo. Error bars indicate the SDs of the means. The limit of detection for the assay was 100 pfu/mL [treatment group (n = 10) and D5W placebo (n = 6)]. P = 0.003 by one-way ANOVA.