Fig. 2.
Intersubunit interactions in the fully ratcheted 70S ribosome. Interface view of the 30S (A) and the 50S (B) subunit with the intersubunit interactions or bridges (numbered as in refs. 18 and 36). Intersubunit interactions are shown as surfaces in red. The B1a bridge is not shown, as it is not well-ordered in our structure. (C) The B2a bridge. Comparison of the conformations of the B2a bridge in the ribosome between the fully rotated state (colored as 16S rRNA in orange and 23S rRNA in blue) and the classical state (light blue) showing the concerted movement of the interacting elements. (D) The B4 bridge. Comparison of the conformations of the B4 bridge in the ribosome between the fully rotated state (colored as protein S15 in orange and 23S rRNA in blue) and the classical state (light blue) showing the concerted movement of the interacting elements. (E) The B8 bridge. Comparison of the conformation of the B8 bridge in the ribosome between the fully rotated state (colored as 16S rRNA in orange, protein L19 in cyan, and protein L14 in deep olive) and the classical state (light blue) showing closer h14 and L14 interactions.