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Conditional Rheb expression in astroglial cells results in increased glial numbers and proliferation in vivo. (A) No effect of Rheb expression on body size or brain weight was observed in RhebGFAP mice. (B) GFAP-Cre-mediated Rheb expression results in increased numbers of pS6 (Ser-240/244) cells, (C) Ki67+ proliferating cells, and (D) GFAP+ cells in vivo. Magnification = 10×. (Insets) Representative pS6+ (B) and Ki67+ (C) cells. (Scale bars, 100 μm.) Bars indicate SEM.
