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. 2011 Aug 11;12(8):5098–5134. doi: 10.3390/ijms12085098

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 4. — Illustration on a ligand-receptor cyclic interaction coordinate of the molecular mechanism of genotoxic carcinogenesis as given by the residual-alert-QSAR correlation-path hierarchy of Equations (13a)–(13c) then summarized in Equation (17). The mechanism is superimposed over an immunohistochemical analysis of paraffin-embedded sections of rat intestinal cancer using the Caspase-2 antibody [51]. In these evolving molecular graphs (the SA region is circumvented), steric movement is represented by mirroring, electronegativity docking by changing SA colors, diffusion by translation arrows; polarizability by vibration arrows, and electrophilic docking (the final stage including the maximum hardness principle) by positive charging.