Table 2.
| |||||
---|---|---|---|---|---|
Cmpd | R | Pharmacology | IC50 (μM)a | EC50 (μMa) | Glu Max (%)a |
(S)-20a | NAM | 2.6 | NA | 11 | |
(R)-20a | NAM | 3.5 | NA | 7 | |
(S)-20b | NAM | 10 | NA | 33 | |
(R)-20b | Inactive | - | - | - | |
(S)-20c | PAM | NA | 0.7 | 71 | |
(R)-20c | PAM | NA | 0.6 | 37 | |
(S)-20d | NAM | 0.9 | NA | 6 | |
(R)-20d | NAM | 10 | NA | 38 | |
(S)-20e | NAM | 0.5 | NA | 3 | |
(R)-20e | NAM | 0.3 | NA | 6 | |
(S)-20f | NAM | 0.08 | NA | 1.8 | |
(R)-20f | NAM | 0.3 | NA | 0.5 |
Average of at least three independent determinations. NA, not applicable.