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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Dec 3;21(9):2711–2714. doi: 10.1016/j.bmcl.2010.11.119

Table 2.

Structures and activities of analogs (S)-20 and (R)-20.

graphic file with name nihms260881u2.jpg
Cmpd R Pharmacology IC50 (μM)a EC50 (μMa) Glu Max (%)a
(S)-20a graphic file with name nihms260881t8.jpg NAM 2.6 NA 11
(R)-20a NAM 3.5 NA 7
(S)-20b graphic file with name nihms260881t9.jpg NAM 10 NA 33
(R)-20b Inactive - - -
(S)-20c graphic file with name nihms260881t10.jpg PAM NA 0.7 71
(R)-20c PAM NA 0.6 37
(S)-20d graphic file with name nihms260881t11.jpg NAM 0.9 NA 6
(R)-20d NAM 10 NA 38
(S)-20e graphic file with name nihms260881t12.jpg NAM 0.5 NA 3
(R)-20e NAM 0.3 NA 6
(S)-20f graphic file with name nihms260881t13.jpg NAM 0.08 NA 1.8
(R)-20f NAM 0.3 NA 0.5
a

Average of at least three independent determinations. NA, not applicable.