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Structures and activities of analogs 23.
 | |||||
|---|---|---|---|---|---|
| Cmpd | R | Pharmacology | IC50 (μM)a | EC50 (μMa) | Glu Max (%)a |
| 23a |
|
PAM | NA | 1.5 | 64 |
| 23b |
|
PAM | NA | 2.7 | 72 |
| 23c |
|
NAM | 10 | NA | 25 |
| 23d |
|
NAM | 2.4 | NA | 34 |
| 23e |
|
Inactive | NA | NA | NA |
| 23f |
|
Inactive | NA | NA | NA |
| 23g |
|
Inactive | NA | NA | NA |
Average of at least three independent determinations. NA, not applicable.
