Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Dose-Limiting Toxicity Summary (course 1)
| MK-0752 mg/m2* | No. of Patients Enrolled | No. of Patients Evaluable | No. of Patients With DLT | DLT |
|---|---|---|---|---|
| 200 | 3 | 3 | 0 | |
| 260 | 6 | 6 | 2 | Grade 3 AST (n = 2); grade 3 ALT (n = 2)† |
| 260 (expanded PK cohort) | 14 | 12 | 1 | Grade 3 ALT (n = 1) |
Abbreviations: DLT, dose-limiting toxicity; PK, pharmacokinetics.
Dosage is expressed in mg/m2/dose administered 3 days on, 4 days off.
Both patients had both AST and ALT DLTs.
