Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Summary of MK-0752 Pharmacokinetic Parameters in Relation to MK-0752 Dosage for Day 1 of Course 1
| Dosage | No. of Patients | Parameter | Median | Range |
|---|---|---|---|---|
| 200 mg/m2 | 1 | AUC (μg/mL·h) | 469 | |
| Cmax (μg/mL) | 23 | |||
| Tmax (h) | 12 | |||
| 260 mg/m2 | 17 | AUC (μg/mL·h) | 413 | 299-655 |
| Cmax (μg/mL) | 25 | 16-39 | ||
| Tmax (h) | 6.0 | 2.2-17 |
Abbreviations: AUC, area under the plasma concentration-time curve; Cmax, maximum concentration; Tmax, time to maximum concentration.
