Table 1.
Biomarker Result | % of Total Patients by Treatment Arm |
||
---|---|---|---|
Erlotinib (n = 72) | CP + Intercalated Erlotinib (n = 71) | Total(N = 143) | |
IHC result | |||
Positive | 93 | 92 | 92 |
Negative | 4 | 8 | 6 |
FISH result | |||
Positive | 54 | 54 | 54 |
Negative | 43 | 46 | 45 |
EGFR mutation result | |||
Mutation | 18 | 17 | 17 |
Activating mutation | 12 | 10 | 11 |
Exon 19 deletion | 11 | 4 | 8 |
Exon 21 L858R mutation | 1 | 6 | 3 |
Other mutation | 6 | 7 | 6 |
No mutation | 67 | 65 | 66 |
KRAS mutation result | |||
Mutation | 18 | 23 | 20 |
No mutation | 75 | 73 | 74 |
E-cadherin | |||
High | 36 | 30 | 33 |
Low | 33 | 38 | 36 |
Vimentin | |||
High | 29 | 17 | 23 |
Low | 40 | 48 | 44 |
Abbreviations: CP, carboplatin/paclitaxel; IHC, immunohistochemistry; FISH, fluorescent in situ hybridization.