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. 2011 Aug 8;29(26):3567–3573. doi: 10.1200/JCO.2010.34.4929

Table 1.

Biomarker Results On the Basis of Treatment Arm and Key Patient Characteristics

Biomarker Result % of Total Patients by Treatment Arm
Erlotinib (n = 72) CP + Intercalated Erlotinib (n = 71) Total(N = 143)
IHC result
    Positive 93 92 92
    Negative 4 8 6
FISH result
    Positive 54 54 54
    Negative 43 46 45
EGFR mutation result
    Mutation 18 17 17
        Activating mutation 12 10 11
            Exon 19 deletion 11 4 8
            Exon 21 L858R mutation 1 6 3
    Other mutation 6 7 6
    No mutation 67 65 66
KRAS mutation result
    Mutation 18 23 20
    No mutation 75 73 74
E-cadherin
    High 36 30 33
    Low 33 38 36
Vimentin
    High 29 17 23
    Low 40 48 44

Abbreviations: CP, carboplatin/paclitaxel; IHC, immunohistochemistry; FISH, fluorescent in situ hybridization.