Table 1.
Vertebral and Femoral Bone Mass and Microarchitectural Parameters in OVX Rats Following Administration and Withdrawal of Treatment With ALN, hPTH(1–34), and RAL (Mean ± SE)
| 4 mo Treatment (Age: 10 mo) | 4 mo withdrawal (Age: 14 mo) | 8 mo withdrawal (Age: 18 mo) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sham | OVX | OVX + ALN | OVX + PTH | OVX + RAL | Sham | OVX | OVX + ALN | OVX + PTH | OVX + RAL | Sham | OVX | OVX + ALN | OVX + PTH | OVX + RAL | |
| Vertebral Trabecular Bone (ex vivo) | |||||||||||||||
| Bone Volume/Total Volume (%) | 31.8 ± 1.0** | 19.2 ± 1.6 | 28.2 ± 1.3** | 29.4 ± 1.2** | 25.2 ± 1.5* | 34.6 ± 1.1** | 18.6 ± 1.4 | 22.8 ± 1.3* | 19.0 ± 1.7 | 21.0 ± 2.2 | 33.3 ± 1.4** | 18.9 ± 1.5 | 23.3 ± 1.0* | 21.4 ± 1.2 | 18.8 ± 1.0 |
| Trabecular Thickness (µm) | 81.5 ± 1.6** | 75.3 ± 1.7 | 81.6 ± 1.7* | 95.8 ± 1.8** | 83.7 ± 2.0** | 89.2 ± 2.0** | 80.7 ± 1.4 | 79.9 ± 1.3 | 76.0 ± 1.8 | 80.4 ± 1.5 | 88.1 ± 1.9** | 77.6 ± 2 | 80.3 ± 1.4 | 80.2 ± 1.2 | 80.0 ± 1.6 |
| Trabecular Number (1/mm) | 3.9 ± 0.1** | 2.9 ± 0.1 | 3.5 ± 0.1** | 3.0 ± 0.1 | 3.1 ± 0.1 | 3.8 ± 0.1** | 2.8 ± 0.1 | 3.2 ± 0.1* | 2.7 ± 0.1 | 2.9 ± 0.1 | 3.8 ± 0.1** | 2.8 ± 0.1 | 3.1 ± 0.1* | 2.8 ± 0.1 | 2.7 ± 0.1 |
| Connectivity Density (1/mm3) | 69.4 ± 3.3 | 55.3 ± 6.9 | 59.9 ± 5.0 | 37.0 ± 1.8* | 44.4 ± 2.8 | 51.0 ± 2.7** | 38.3 ± 2.0 | 49.4 ± 2.9** | 42.6 ± 2.5 | 44.2 ± 3.5 | 44.0 ± 2.6 | 39.7 ± 3.3 | 53.2 ± 2.7** | 45.6 ± 2.2 | 37.7 ± 2.7 |
| Trabecular Separation (µm) | 254 ± 9** | 352 ± 17 | 276 ± 12** | 323 ± 11 | 312 ± 13 | 256 ± 6** | 350 ± 17 | 302 ± 8* | 384 ± 20 | 353 ± 18 | 261 ± 7** | 344 ± 19 | 308 ± 7* | 362 ± 13 | 374 ± 17 |
| Mineral Density of Bone Tissue (mgHA/cm3) | 1119 ± 9* | 1100 ± 8 | 1092 ± 18 | 1107 ± 14 | 1105 ± 9 | 1115 ± 14 | 1105 ± 6 | 1106 ± 13 | 1099 ± 12 | 1099 ± 10 | 1135 ± 11 | 1118 ± 13 | 1123 ± 10 | 1116 ± 11 | 1120± 11 |
| Femoral Cortical Bone | |||||||||||||||
| Cortical Thickness (mm) | 0.66 ± 0.01 | 0.63 ± 0.01 | 0.68 ± 0.01** | 0.68 ± 0.01** | 0.68 ± 0.01* | 0.67 ± 0.01 | 0.64 ± 0.01 | 0.69 ± 0.01** | 0.64 ± 0.01 | 0.65 ± 0.01 | 0.67 ± 0.01* | 0.64 ± 0.01 | 0.70 ± 0.01** | 0.67 ± 0.01 | 0.64 ± 0.01 |
| Bone Volume (mm3) | 5.53 ± 0.09* | 5.81 ± 0.07 | 6.28 ± 0.1** | 6.13 ± 0.1* | 6.0 ± 0.1 | 5.80 ± 0.3 | 5.95 ± 0.3 | 6.25 ± 0.3* | 6.07 ± 0.3 | 6.04 ± 0.3 | 5.76 ± 0.04 | 5.87 ± 0.1 | 6.51 ± 0.06** | 6.23 ± 0.1* | 6.15 ± 0.2 |
| Mineral Density of Bone Tissue (mgHA/cm3) | 1133 ± 6 | 1125 ± 5 | 1127 ± 5 | 1138 ± 4* | 1129 ± 3 | 1120 ± 4 | 1123 ± 3 | 1121 ± 4 | 1123 ± 2 | 1126 ± 4 | 1135 ± 2 | 1129 ± 6 | 1143 ± 3* | 1125 ± 6 | 1125 ± 4 |
*
Different from OVX (p < .05) in the same age group.
**
Different from OVX (p < .001) in the same age group.