Table 2.

Incident Fractures, by Location, in Relation to Body Mass Index Among Older Men, the Osteoporotic Fractures in Men (MrOS) Study

	Normal (18.5–24.9 kg/m2) (n = 1628)	Overweight (25–29.9 kg/m2) (n = 3049)	Obese I (30–34.9 kg/m2) (n = 1034)	Obese II (35–39.9 kg/m2) (n = 207)
Nonspine fractures
No. fractures/person-years	202/10,468	309/20,480	97/6878	24/1356
Incidence ratea	19.3	15.1	14.1	17.7
Adjusted hazard ratios
Age and race	Ref	0.81 (0.68–0.97)	0.83 (0.65–1.05)	1.08 (0.71–1.66)
Age, race, and BMD	Ref	1.04 (0.87–1.25)	1.29 (1.00–1.67)	1.94 (1.25–3.02)
Full modelb	Ref	1.02 (0.84–1.23)	1.12 (0.86–1.46)	1.44 (0.90–2.28)
Hip fractures
No. fractures/person-years	48/11,021	61/21,354	12/7157	5/1403
Incidence ratea	4.4	2.9	1.7	3.6
Adjusted hazard ratios
Age and race	Ref	0.72 (0.49–1.05)	0.65 (0.35–1.19)	1.17 (0.42–3.29)
Age, race, and BMD	Ref	1.25 (0.82–1.89)	1.76 (0.92–3.34)	5.04 (1.74–14.6)
Full modelb	Ref	1.24 (0.78–1.97)	1.34 (0.66–2.74)	3.17 (1.04–9.71)
Upper extremity fractures
No. fractures/person-years	53/10,937	84/21,203	21/7105	6/1401
Incidence ratea	4.8	4.0	3.0	4.3
Adjusted hazard ratios
Age and race	Ref	0.92 (0.65–1.31)	0.77 (0.46–1.28)	1.17 (0.50–2.76)
Age, race, and BMD	Ref	1.25 (0.87–1.80)	1.35 (0.78–2.32)	2.43 (1.00–5.90)
Full modelb	Ref	1.33 (0.92–1.94)	1.27 (0.73–2.21)	1.85 (0.70–4.92)
Lower extremity fractures
No. fractures/person-years	22/10,986	61/21,172	24/7070	6/1398
Incidence ratea	2.0	2.9	3.4	4.3
Adjusted hazard ratios
Age and race	Ref	1.34 (0.84–2.14)	1.56 (0.89–2.74)	1.71 (0.66–4.44)
Age, race, and BMD	Ref	1.59 (0.99–2.56)	2.15 (1.20–3.87)	2.57 (0.97–6.79)
Full modelb	Ref	1.54 (0.94–2.53)	1.84 (0.98–3.46)	1.82 (0.66–5.00)

^aPer 1000 person-years.

^bAdjusted for age, race, total-hip BMD, baseline history of fracture, self-reported mobility limitation, and narrow walk pace. Upper extremity fractures include arm, shoulder, and wrist. Lower extremity fractures include leg and ankle.