Table 1.
Cortical Parameters of the Femoral Midshaft of Col-Cre EgfrWa5/f Mice Measured by pQCT
| Female | Male | |||
|---|---|---|---|---|
| Wild type | Col-Cre EgfrWa5/f | Wild type | Col-Cre EgfrWa5/f | |
| 3 months | ||||
| Cortical BMD (mg/cm3) | 1073.8 ± 7.6 | 1059.7 ± 18.7 | 1111.2 ± 9.9 | 1098.9 ± 10.1 |
| Cortical area (mm2) | 1.22 ± 0.02 | 1.09 ± 0.03a | 1.58 ± 0.04 | 1.42 ± 0.03a |
| Cortical thickness (mm) | 0.403 ± 0.008 | 0.384 ± 0.007 | 0.440 ± 0.007 | 0.431 ± 0.009 |
| Periosteal perimeter (mm) | 4.30 ± 0.04 | 4.04 ± 0.08a | 4.98 ± 0.06 | 4.65 ± 0.06a |
| Endosteal perimeter (mm) | 1.77 ± 0.08 | 1.63 ± 0.08 | 2.21 ± 0.06 | 1.94 ± 0.09b |
| Length (cm) | 1.57 ± 0.012 | 1.53 ± 0.02b | 1.62 ± 0.01 | 1.56 ± 0.01a |
| 7 months | ||||
| Cortical BMD (mg/cm3) | 1196.2 ± 9.5 | 1153.2 ± 18.6 | 1195.0 ± 10.5 | 1139.9 ± 31.4 |
| Cortical area (mm2) | 1.39 ± 0.04 | 1.22 ± 0.04a | 1.65 ± 0.03 | 1.51 ± 0.07 |
| Cortical thickness (mm) | 0.451 ± 0.009 | 0.429 ± 0.016 | 0.476 ± 0.010 | 0.457 ± 0.021 |
| Periosteal perimeter (mm) | 4.50 ± 0.07 | 4.21 ± 0.07a | 4.97 ± 0.05 | 4.78 ± 0.11 |
| Endosteal perimeter (mm) | 1.67 ± 0.08 | 1.51 ± 0.12 | 1.98 ± 0.08 | 1.91 ± 0.17 |
| Length (cm) | 1.61 ± 0.02 | 1.53 ± 0.02b | 1.64 ± 0.01 | 1.55 ± 0.01a |
a
p < .005
b
p < .05 versus age- and sex- matched wild-type mice.