Table 3.
Cortical Parameters of the Femoral Midshaft of EgfrDsk5/+ Mice Measured by pQCT
| Female | Male | |||
|---|---|---|---|---|
| Wild type | EgfrDsk5/+ | Wild type | EgfrDsk5/+ | |
| 3 months | ||||
| Cortical BMD (mg/cm3) | 1087.3 ± 8.8 | 1110.2 ± 8.1 | 1137.5 ± 12.3 | 1159.3 ± 11.5 |
| Cortical area (mm2) | 1.05 ± 0.03 | 1.07 ± 0.03 | 1.22 ± 0.07 | 1.24 ± 0.05 |
| Cortical thickness (mm) | 0.382 ± 0.009 | 0.412 ± 0.013 | 0.445 ± 0.013 | 0.493 ± 0.015c |
| Periosteal perimeter (mm) | 3.95 ± 0.07 | 3.90 ± 0.06 | 4.14 ± 0.13 | 4.06 ± 0.09 |
| Endosteal perimeter (mm) | 1.55 ± 0.10 | 1.31 ± 0.11 | 1.44 ± 0.07 | 1.14 ± 0.05b |
| Length (cm) | 1.52 ± 0.01 | 1.50 ± 0.01 | 1.56 ± 0.02 | 1.55 ± 0.01 |
| 6 months | ||||
| Cortical BMD (mg/ cm3) | 1183.4 ± 9.0 | 1214.7 ± 10.1c | 1189.5 ± 9.2 | 1211.2 ± 7.736 |
| Cortical area (mm2) | 1.34 ± 0.02 | 1.31 ± 0.01 | 1.34 ± 0.03 | 1.35 ± 0.03 |
| Cortical thickness (mm) | 0.444 ± 0.008 | 0.487 ± 0.018b | 0.443 ± 0.009 | 0.505 ± 0.011a |
| Periosteal perimeter (mm) | 4.42 ± 0.03 | 4.23 ± 0.02a | 4.41 ± 0.05 | 4.27 ± 0.05c |
| Endosteal perimeter (mm) | 1.63 ± 0.05 | 1.17 ± 0.13b | 1.63 ± 0.07 | 1.10 ± 0.09a |
| Length (cm) | 1.63 ± 0.01 | 1.62 ± 0.01 | 1.57 ± 0.01 | 1.60 ± 0.01b |
a
p < .001
b
p < .01
c
p < .05 versus age- and sex-matched wild-type mice.