Fig. 3.

Periosteal bone formation induced by PTH receptor signaling in osteocytes is reduced in mice lacking LRP5. (A) Representative images of histologic sections show fluorochrome incorporation in femoral mid-diaphyses of 12-week-old WT and DMP1-caPTHR1 mice with or without LRP5. (B) Static and dynamic histomorphometric measurements were determined in 3–4 male and female mice per group. Values are means ± SD. *p < .05 versus respective controls without the DMP1-caPTHR1 transgene; ^#p < .05 versus DMP1-caPTHR1 mice.