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Periosteal bone formation induced by PTH receptor signaling in osteocytes is abolished by overexpression of Sost in osteocytes. (A) Representative images of histologic sections show fluorochrome incorporation in femoral mid-diaphyses of 10.5-week-old WT and DMP1-caPTHR1 mice with or without the DMP1-Sost transgene. (B) Static and dynamic histomorphometric measurements were determined in 3–5 mice per group. Values are means ± SD. *p < .05 versus WT mice.
