Fig. 6.

The increased bone resorption induced by PTH receptor signaling in osteocytes persists in the absence of LRP5 and is exacerbated by Sost overexpression. (A,B) TRAPase/von Kossa staining of calvarial sections and histomorphometric quantification of calvarial marrow space, expressed as the area occupied by marrow versus bone in the mid-third of one frontal bone, and of osteoclasts, expressed as number per bone area. n = 4 mice/group. Bar indicates 50 µm. (C) Osteocalcin and CTX were measured in plasma of 10.5-week-old DMP1-caPTHR1 mice, with and without the DMP1-Sost transgene. Bars represent the mean ± SD; n = 7–23 mice per group. *p < .05 versus WT and LRP5^−/− or DMP1-Sost mice, respectively; ^#p < .05 versus DMP1-caPTHR1 mice.