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. 2010 Jul 23;26(1):100–112. doi: 10.1002/jbmr.193

Table 3.

Selected Gene Groups Present in the Bone-Formation (Down) Clusters, Which Were Downregulated During Matrix Formation

Gene group Cluster Gene name
Calcium signaling
Asph H Aspartate-β-hydroxylase
Cab39l L Calcium-binding protein 39-like
Calb2 H Calbindin 2
Camk2b H Calcium/calmodulin-dependent protein kinase (CaM kinase) IIβ
Casq2 H Calsequestrin 2
Pvalb H Parvalbumin
Stc2 L Stanniocalcin 2
Trdn H Triadin
Cell cycle
Ccna2 L Cyclin A2
Ccnb1 L Cyclin B1
Cdc25b L Cell division cycle 25 homologue B
Cenpc1 L Centromere protein C1
Chemokine
Ccl11 L Chemokine (C–C motif) ligand 11
Ccr1 L Chemokine (C–C motif) receptor 1
Ccr2 L Chemokine (C–C motif) receptor 2
Ccr3 L Chemokine (C–C motif) receptor 3
Cxcl12 L Chemokine (C–X–C motif) ligand 12
Cxcl14 H Chemokine (C–X–C motif) ligand 14
Cxcr5 L Chemokine (C–X–C motif) receptor 5
Cytokine
Asb2 H Ankyrin repeat and SOCS box-containing 2
Il8rb L Interleukin 8 receptor, β
Tnfsf10 H Tumor necrosis factor (ligand) superfamily, member 10 (TRAIL)
Tnfrsf14 L Tumor necrosis factor receptor superfamily, member 14
Growth factor
Egf L Epidermal growth factor
Fgf1 L Fibroblast growth factor 1
Fgf7 H Fibroblast growth factor 7
Fgf23 H Fibroblast growth factor 23
Fgl2 H Fibrinogen-like 2
Hgf L Hepatocyte growth factor
Igfbp6 L Insulin-like growth factor–binding protein 6
Ion channel
Cacnb1 H Calcium channel, voltage-dependent, β1 subunit
Cacng1 H Calcium channel, voltage-dependent, γ subunit 1
Cacng7 H Calcium channel, voltage-dependent, γ subunit 7
Clca2 L Chloride channel calcium activated 2
Clic5 L Chloride intracellular channel 5
Hcn4 L Hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Kcnj3 L Potassium inwardly rectifying channel, subfamily J, member 3
Kcnj11 H Potassium inwardly rectifying channel, subfamily J, member 11
Kcnj12 H Potassium inwardly rectifying channel, subfamily J, member 12
Kcnn4 L Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Sclt1 L Sodium channel and clathrin linker 1
Scn4a H Sodium channel, voltage-gated, type 4, α subunit
Scn4b H Sodium channel, type IV, β
Scn7a L Sodium channel, voltage-gated, type VII, α
Matrix
Efemp1 H EGF-containing fibulin-like extracellular matrix protein 1
Mmp8 L Matrix metallopeptidase 8
Prelp L Proline arginine–rich end leucine-rich repeat protein
Serpinb2 L Serine (or cysteine) peptidase inhibitor, clade B, member 2
Spon1 L Spondin 1
Muscle
Acta1 H Actin, α1
Actn3 H Actinin, α3
Ampd1 H Adenosine monophosphate deaminase 1 (isoform M)
Des H Desmin
Dmd H Dystrophin, muscular dystrophy
Gyg1 H Glycogenin 1
Mb H Myoglobin
Myl1 H Myosin, light polypeptide 1
Mylk2 H Myosin light chain kinase 2
Mylpf H Myosin light chain, phosphorylatable, fast
Myocd H Myocardin
Smpx H Small muscle protein, X-linked
Synm H Synemin
Tnni2 H Troponin I type 2
Tnnt3 H Troponin T type 3
Tpm2 L Tropomyosin 2
Neurotransmitter
Chrna1 H Cholinergic receptor, nicotinic, α1
Chrnb1 H Cholinergic receptor, nicotinic, β1
Chrne H Cholinergic receptor, nicotinic, ɛ
Htr1b L 5-Hydroxytryptamine (serotonin) receptor 1B
Maob L Monoamine oxidase B
Solute carrier
Slc2a1 H Solute carrier family 2 (facilitated glucose transporter), member 1
Slc4a1 L Solute carrier family 4 (anion exchanger), member 1
Slc6a4 L Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Slc6a20 L Solute carrier family 6 (neurotransmitter transporter), member 20
Slc14a1 L Solute carrier family 14 (urea transporter), member 1
Slc15a2 L Solute carrier family 15 (H+/peptide transporter), member 2
Slc16a1 L Solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Slc16a3 H Solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
Slc16a6 L Solute carrier family 16, member 6 (monocarboxylic acid transporter 7)
Slc22a3 H Solute carrier family 22 (extraneuronal monoamine transporter), member 3
Slc25a11 L Solute carrier family 25 (mitochondrial carrier, oxoglutarate carrier), member 11
Slc25a30 L Solute carrier family 25, member 30
Slc38a1 L Solute carrier family 38, member 1
Slc38a3 L Solute carrier family 38, member 3
Slco1a4 H Solute carrier organic anion transporter family, member 1a4
TGF-β signaling
Bmpr1b H Bone morphogenetic protein receptor, type IB
Chrdl1 L Chordin-like 1
Grem1 H Gremlin 1, cysteine knot superfamily
Tgfbr3 L Transforming growth factor, β receptor III
Ubiquitin
Usp1 L Ubiquitin-specific peptidase 1
Usp15 L Ubiquitin-specific peptidase 15
Wnt/β-catenin signaling (inhibitors)
Sfrp4 H Secreted frizzled-related protein 4
Sost L Sclerosteosis
Other
Adrb2 H Adrenergic, β2, receptor, surface
Casp1 L Caspase 1
Fcn1 L Ficolin (collagen/fibrinogen domain containing) 1
Lepr L Leptin receptor
Mustn1 L Musculoskeletal, embryonic nuclear protein 1
Ptgds2 L Prostaglandin D2 synthase 2, hematopoietic
Rsad2 L Radical S-adenosyl methionine domain containing 2

H = high-magnitude cluster; L = low-magnitude cluster.