Table 4.

Unadjusted Urinary NTX Level According to Presence of VMS by Menopausal Transition Stage^a

	VMS any versus noneb				VMS frequent versus not frequentc
		NTX leveld				Ntx level
	VMS	Mean	SD	p Valuee	VMS	Mean	SD	p Valuef
Premenopausal	Overall (n = 2500)	33.51	15.45
	None (n = 1739)	33.37	15.64	.48	Not frequent (n = 2323)	33.45	15.56	.44
	Any (n = 761)	33.84	15.02		Frequent (n = 177)	34.38	13.97
Early perimenopausal	Overall (n = 6066)	34.64	16.69
	None (n = 3241)	33.92	15.76	<.001	Not frequent (n = 5218)	34.20	16.30	<.001
	Any (n = 2825)	35.47	17.66		Frequent (n = 848)	37.35	18.70
Late perimenopausal	Overall (n = 1040)	43.30	19.04
	None (n = 324)	42.44	18.22	.33	Not frequent (n = 677)	42.22	18.40	.01
	Any (n = 716)	43.69	19.40		Frequent (n = 363)	45.31	20.05
Postmenopausal	Overall (n = 2529)	47.03	24.97
	None (n = 995)	45.73	28.06	.04	Not frequent (n = 1793)	46.53	26.24	.09
	Any (n = 1534)	47.88	22.72		Frequent (n = 736)	48.26	21.56

^aValues of NTX (nM BCE/mM of creatinine) are averages over all years of follow-up within the given menopausal stage.

^bWomen were considered to have vasomotor symptoms if they reported experiencing hot flashes or night sweats or both in the past 2 weeks on annual questionnaires.

^c“Frequent VMS” indicates VMS frequency ≥ 5 days in the past 2 weeks; “Not frequent VMS” indicates VMS frequency < 5 days in the past 2 weeks.

^dUnits of NTX are nM BCE/mM of creatinine.

^ep Value for t test comparing mean NTX level of women with any VMS with the mean NTX level of women with no VMS.

^fp Value for t test comparing mean NTX level of women with frequent VMS with the mean NTX level of women without frequent VMS.