Table 5.

Associations Between VMS and Urinary NTX Level in Multivariable-Adjusted Models^a

	VMS any versus none: basic model			VMS frequent versus not frequent: basic modelb
Menopausal stage	β coefficientc	SD	p Value	β coefficientd	SD	p Value
Premenopausal	1.017	0.809	.17	0.741	1.436	.61
Early perimenopausal	1.944	0.486	<.0001	3.077	0.675	<.0001
Late perimenopausal	2.437	1.011	.03	3.625	1.069	<.001
Postmenopausal	1.259	0.769	.10	1.909	0.799	.02

	VMS any versus none: model with FSHe			VMS frequent versus not frequent: model with FSH
Menopausal stage	β coefficient	SD	p Value	β coefficient	SD	p Value
Premenopausal	0.802	0.805	.32	0.391	1.430	.78
Early perimenopausal	1.347	0.486	.006	2.024	0.676	.003
Late perimenopausal	1.071	1.107	.33	2.519	1.073	.02
Postmenopausal	0.546	0.769	.48	0.919	0.801	.25

	VMS any versusnone: model with estradiolf			VMS frequent versus not frequent: model with estradiol
Menopausal stage	β coefficient	SD	p Value	β coefficient	SD	p Value
Premenopausal	0.969	0.812	.23	0.701	1.442	.63
Early perimenopausal	1.784	0.489	<.001	2.827	0.679	<.0001
Late perimenopausal	2.022	1.113	.07	3.294	1.079	.002
Postmenopausal	1.307	0.774	.09	1.748	0.805	.06

	VMS any versus none: model with FSH and estradiolg			VMS frequent versus not frequent: model with FSH and estradiol
Menopausal stage	β coefficient	SD	p Value	β coefficient	SD	p Value
Premenopausal	0.787	0.805	.33	0.443	1.430	.76
Early perimenopausal	1.336	0.486	.006	1.022	0.676	.003
Late perimenopausal	1.042	1.107	.35	2.492	1.073	.02
Postmenopausal	0.557	0.769	.47	0.930	0.801	.25

^aRepeated-measures models adjusted for age, smoking, BMI, race/ethnicity, calcium and vitamin D supplement intake, physical activity score (log-transformed), alcohol intake (kcal/d, log-transformed), and study site.

^b“Frequent VMS” indicates VMS frequency ≥ 5 days in the past 2 weeks; “Not frequent VMS” indicates VMS frequency < 5 days in the past 2 weeks.

^cβ coefficient represents the increment in urinary NTX (nM BCE/mM of creatinine) associated with reporting any VMS versus no VMS.

^dβ coefficient represents the increment in urinary NTX (nM BCE/mM of creatinine) comparing frequent VMS with not frequent VMS.

^eIncludes variables of basic model, follicle-stimulating hormone level (FSH, IU/L) and menstrual cycle phase (follicular versus not follicular or unknown phase).

^fRepeated-measures models adjusted for variables of the basic model, serum estradiol concentration (pg/mL), and menstrual cycle phase.

^gRepeated-measures models adjusted for variables of the basic model, serum FSH level, serum estradiol concentration, and menstrual cycle phase.