Table 2.
Mean Trabecular Bone Traits (± SD) for 8-Week-Old Male Control and LID Mice Treated with Vehicle or Pegvisomant
| Control | Vehicle n = 14 | Pegvisomant n = 10 |
|---|---|---|
| BV/TV (%) | 14.7 ± 2.7 | 15.1 ± 1.6 |
| Tb.Th (mm)* | 0.028 ± 0.002 | 0.032 ± 0.001 |
| Tb.N (mm−1) | 5.3 ± 0.5 | 4.8 ± 0.4 |
| Tb.Sp(mm) | 0.163 ± 0.021 | 0.180 ± 0.020 |
| TMD (mg/cc)* | 590 ± 37 | 664 ± 40 |
| LID | Vehicle n = 16 | Pegvisomant n = 11 |
|---|---|---|
| BV/TV (%) | 16.7 ± 5.0 | 12.6 ± 5.3 |
| Tb.Th (mm) | 0.029 ± 0.003 | 0.027 ± 0.003 |
| Tb.N (mm−1)* | 5.8 ± 1.2 | 4.5 ± 1.4 |
| Tb.Sp (mm)* | 0.153 ± 0.045 | 0.215 ± 0.072 |
| TMD (mg/cc) | 638 ± 49 | 607 ± 40 |
*
Significant difference between vehicle and pegvisomant treatment, ANOVA, p < .05.