Figure 1.

Domain architectures of thrombospondins. (A) Schematic diagram of the domain architectures of thrombospondin family members. Key: LG = laminin G-like amino-terminal domain; vWF_C = von Willebrand type C domain; TSR = thrombospondin type 1 domains; EGF = epidermal growth factor-like domains; Type 3 = thrombospondin type 3 repeats; L-lectin = L-type lectin-like domain; DD = discoidin domain; IVR = intervening region; CX2C = Cys-X2-Cys domain; CB = chitin-binding type 2 domain. Horizontal red lines indicate coiled-coil domains. Vertical black lines indicate position of cysteine residues that form intersubunit disulfide bonds. (B) Examples of the coiled-coil oligomerization domain from representative trimeric and pentameric thrombospondins. Asterisks indicate cysteines that form intersubunit disulfide bonds.