Table 4.

Mapped binding partners

TSP domain	Motif	Binding partner	Reference
LG-NTD	Positive patch involving R29,K32,R42,R77,K80,K81, K106a MKKTRGa E17LTGAARKGSGRRLVKGPDaA159ELDVPaI151DCEKMENAELDVPa	HS-glycosaminoglycansDecorinCalreticulinα4 Integrin Fibrinogen	Lawler et al. 1992; Tan et al. 2006,Merle et al. 1997,Murphy-Ullrich et al. 1993; Goicoechea et al. 2000,Calzada et al. 2004a,Voland et al. 2000
Type 1 repeats	WSXWSeCSVTCGeW420SHWSPWcK412RFKb	HS-glycosaminoglycansCD36TGF-β bindingTGF-β activationb	Guo et al. 1992,Asch et al. 1992,Schulz-Cherry et al. 1995,Ribeiro et al. 1999
Type 3 repeats	RGDa,d	β1 Integrin, β3 integrin	Lawler et al. 1988; Lawler and Hynes 1989; Chen et al. 2005;
	KGD	PS2 Integrin	Chanana et al. 2007; Subramanian et al. 2007
L-type lectin domain	GVDFEGTFHVNTVTDDD	Fibrillar collagendCollagen IXdMatrilin-3d	Holden et al. 2001

Binding partners of thrombospondins. The interactions listed are those for which the binding site has been mapped within the relevant TSP domain and is surface-exposed in the domain structure, as determined by X-ray crystallography.

^aIdentified in TSP-1.

^bSpecific to TSP-1.

^cPresent in the second type 1 domain of both TSP-1 and TSP-2.

^dIdentified for TSP-5/COMP. The DDD motif is also surface-exposed in TSP-1 and TSP-2 and is conserved in most TSPs.