Table 3.
Pharmacogenomic tests offered by three primary DTC genomic testing companies as of June 2011
| Drug/health issue | Indications | Pathway Genomics | Navigenics | 23andMe |
|---|---|---|---|---|
| Abacavir hypersensitivity | HIV treatment | x | x | x |
| Aminoglycoside-induced ototoxicity | Antibiotic for treatment of severe bacterial infections | x | ||
| Antidepressant response | Depression, anxiety | x | ||
| Azathiopurine/6-Mercaptopurine | Anti-inflammatory, treatment of autoimmune disorders or cancer | x | ||
| Beta-blockers | Treat high blood pressure, irregular heartbeat, | x | x | |
| Carbamazepine | Epilepsy, bipolar disorder | x | x | |
| Clopidogrel efficacy | Prevent blood clots | x | x | x |
| Estrogen-containing medications | Oral contraceptives, HRT | x | x | |
| Floxacillin toxicity | Antibiotic used for staphylococcal infections | x | x | |
| Fluorouracil toxicity | Chemotherapy drug used to treat cancer | x | x | |
| Interferon beta response | Multiple sclerosis treatment | x | ||
| Irinotecan | Chemotherapy drug to treat colorectal cancer | x | ||
| Lumiracoxib side effects | Treatment of acute pain and symptoms of osteoarthritis | x | ||
| Metformin response | Treat type 2 diabetes | x | ||
| Methotrexate toxicity | Antimetabolite/antifolate for cancer/autoimmune disease | x | ||
| Naltrexone response | Alcohol and heroin addiction | x | ||
| PEG-IFNalpha/RBV response | Hepatitis C treatment | x | ||
| PONV reactions | General anesthesia | x | ||
| Pseudocholinesterase deficiency | Stop skeletal muscle contractions; used as part of anesthesia | x | x | |
| Simvastatin/Pravastatin response | Lower cholesterol, stroke prevention | x | x | |
| Simvastatin-induced myopathy | Lower cholesterol, stroke prevention | x | x | x |
| Tamoxifen response | Treatment and prevention of breast cancer | x | ||
| Warfarin sensitivity | Blood thinner | x | x | x |