Table 2.
Genotype-phenotype associations for secondary platelet aggregation phenotypes in GeneSTAR (for SNPs common to participants of EA and African ancestry)
| SNP | Baseline aggregation phenotypes |
After aspirin aggregation phenotypes adjusted for baseline |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Col2 | Col5 | ADP2 | ADP10 | Epi2 | Epi10 | Col2 | Col5 | ADP2 | ADP10 | Epi2 | Epi10 | |
| European ancestry | ||||||||||||
| rs2644604 | .0798 | .0161 | .0002 | .0002 | .0012 | .0060 | .0011 | .0001 | .2318 | .0587 | .0003 | .0097 |
| rs12566888 | .0229 | .1252 | 2.60 × 10−6 | .0371 | 7.08 × 10−5 | .0005 | 1.12 × 10−5 | .0001 | .1327 | .0288 | 9.72 × 10−6 | .0026 |
| rs12041331 | .3077 | .0166 | .0001 | .0045 | 3.08 × 10−5 | .0010 | 8.98 × 10−6 | 1.60 × 10−5 | .0730 | .0276 | .0003 | .0015 |
| African ancestry | ||||||||||||
| rs2644604 | 5.23 × 10−7 | .0157 | .0002 | .0020 | 3.58 × 10−7 | 2.83 × 10−6 | 0.0003 | 5.78 × 10−5 | .0034 | .0013 | .0001 | 1.70 × 10−5 |
| rs12566888 | .0002 | .1867 | 3.12 × 10−5 | 6.83 × 10−7 | 1.39 × 10−8 | 7.59 × 10−8 | 3.47 × 10−6 | 1.12 × 10−8 | .0143 | .0029 | .0024 | .0016 |
| rs12041331 | .0002 | .0020 | 2.28 × 10−9 | 6.29 × 10−8 | 9.97 × 10−17 | 1.81 × 10−12 | 1.40 × 10−7 | 4.89 × 10−12 | 3.55 × 10−5 | 1.56 × 10−7 | 6.31 × 10−6 | 9.10 × 10−7 |
P values are shown for each genotype-phenotype association signal.
Col2 and 5 indicates aggregation to collagen 2 and 5 μg/mL, respectively; ADP2 and 10, aggregation to adenosine diphosphate 2 and 10μM, respectively; and Epi 2 and 10, aggregation to epinephrine 2 and 10μM, respectively.