Table 1.

Patient and tumor characteristics for pre- and perimenopausal patients with lymph-node-negative breast cancer and cohorts defined according to estrogen receptor (ER) status

	Goserelin × 24, n (%)	CMF × 6, n (%)	CMF × 6→goserelin × 18, n (%)	Total, n (%)
ER-positive cohort	n = 278	n = 291	n = 282	n = 851
Age (years)
≤34	11 (4)	16 (6)	16 (6)	43 (5)
35–39	36 (13)	36 (12)	37 (13)	109 (13)
40–44	65 (23)	88 (30)	69 (24)	222 (26)
45–49	115 (41)	105 (36)	105 (37)	325 (38)
≥50	51 (18)	46 (16)	55 (20)	152 (18)
Primary surgical treatment
Total mastectomy	119 (43)	126 (43)	121 (43)	366 (43)
Breast conservation
With RT planned	148 (53)	151 (52)	146 (52)	445 (52)
With no RT planned	11 (4)	14 (5)	15 (5)	40 (5)
Tumor size (cm)
≤1.0	27 (10)	37 (13)	44 (16)	108 (13)
1.1–2.0	149 (54)	151 (52)	146 (52)	446 (52)
>2	100 (36)	98 (34)	90 (32)	288 (34)
Unknown	2 (1)	5 (2)	2 (1)	9 (1)
Tumor grade
1	52 (19)	46 (16)	77 (27)	175 (21)
2	148 (53)	146 (50)	129 (46)	423 (50)
3	76 (27)	93 (32)	74 (26)	243 (29)
Unknown	2 (1)	6 (2)	2 (1)	10 (1)
ER-negative cohort	n = 65	n = 68	n = 72	n = 205
Age (years)
≤34	5 (8)	6 (9)	4 (6)	15 (7)
35–39	15 (23)	10 (15)	16 (22)	41 (20)
40–44	15 (23)	18 (26)	22 (31)	55 (27)
45–49	24 (37)	24 (35)	20 (28)	68 (33)
≥50	6 (9)	10 (15)	10 (14)	26 (13)
Primary surgical treatment
Total mastectomy	34 (52)	31 (46)	35 (49)	100 (49)
Breast conservation
With RT planned	27 (42)	30 (44)	33 (46)	90 (44)
With no RT planned	4 (6)	7 (10)	4 (6)	15 (7)
Tumor size (cm)
≤1.0	5 (8)	5 (7)	5 (7)	15 (7)
1.1–2.0	31 (48)	21 (31)	28 (39)	80 (39)
>2	29 (45)	42 (62)	37 (51)	108 (53)
Unknown	0 (0)	0 (0)	2 (3)	2 (1)
Tumor grade
1	1 (2)	2 (3)	3 (4)	6 (3)
2	12 (18)	16 (24)	16 (22)	44 (21)
3	52 (80)	49 (72)	51 (71)	152 (74)
Unknown	0 (0)	1 (1)	2 (3)	3 (1)

CMF, cyclophosphamide, methotrexate and fluorouracil; RT, radiation therapy.