Table 3.
Significant differences in the clinical characteristics of patients with NNHCA-IE compared to community-acquired IE, as determined by multivariate analysis
| NNHCA-IE | Community- | Univariate | Multivariate 1 | |||
|---|---|---|---|---|---|---|
| n = 30 | acquired IE n = 148 |
OR (95%CI) | p value | OR (95%CI) | p value | |
| Age ≧ 65 years, n (%) | 19 (63.3) | 27 (18.2) | 7.7 (3.3-18.1) | < 0.001 | ||
| Women, n (%) | 13 (43.3) | 28 (18.9) | 3.3 (1.4-7.5) | 0.004 | ||
| Charlson comorbidity index ≧ 2 n (%) | 27 (90.0) | 27 (18.2) | 40.3 (11.4-142.7) | < 0.001 | 27.5 (6.9-110.3) | < 0.001 |
| Diabetes mellitus, n (%) | 17 (56.7) | 25 (16.9) | 6.4 (2.8-14.9) | < 0.001 | ||
| Hypertension, n (%) | 20 (66.7) | 26 (17.6) | 9.4 (3.9-22.4) | < 0.001 | 7.5 (2.2-25.1) | 0.001 |
| Symptoms duration ≦ 7 days n (%) | 25 (83.3) | 95 (64.2) | 2.8 (1.0-7.7) | 0.041 | ||
| Staphylococci infection, n (%) | 23 (76.7) | 75 (50.7) | 3.2 (1.3-7.9) | 0.009 | ||
| MRSA infection, n (%) | 13 (43.3) | 14 (9.5) | 7.3 (3.0-18.1) | < 0.001 | 12.2 (2.9-51.5) | 0.001 |
| Streptococci infection, n (%) | 4 (13.3) | 51 (34.5) | 0.3 (0.1-0.9) | 0.022 | ||
1 Adjusted for age and sex
NNHCA-IE, non-nosocomial healthcare-associated infective endocarditis; OR, odds ratio; CI, confidence interval; MRSA, methicillin-resistant Staphylococcus aureus