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. 2011 Sep 23;6(9):e25177. doi: 10.1371/journal.pone.0025177

Figure 5. Rapamycin regulates memory CTLs and CD62L expression in different time windows.

Figure 5

Sorted OT1 cells were stimulated with antigen+B7+IL-12 in the presence of rapamycin at 250 ng/ml for different windows. Programmed CTLs were harvested at 72 hrs, and transfer into naïve B6 mice at 106/mouse. Memory OT1 cells were examined in spleen at day 30 after transfer for analysis of memory size (A), expression of CD62L (B–C) and production of IFNγ (D). Every group was compared to control group (0–72) in A and C.