Table 2. Genital soluble HLA-G levels in HIV-1-uninfected CSWs, HIV-1-infected CSWs, and HIV-1- uninfected non-CSW women according to the HLA-G gene polymorphism.
| HLA-G | HIV-1- uninfected | HIV-1-infected | HIV-1 uninfected | P-valuea | Total population | P-valueb | ||||
| CSWs | CSWs | non-CSWs | ||||||||
| allelec | N | Levels | N | Levels | N | Levels | N | Levels | ||
| 01:01:01 | 34 | 59.4 (148) | 20 | 113 (230) | 33 | 48.0 (86) | NS | 87 | 67.0 (152) | NS |
| 01:01:02 | 15 | 64.5 (203) | 14 | 191 (259) | 15 | 3.9 (12) | 0.034d | 44 | 84.0 (200) | NS |
| 01:03 | 11 | 47.8 (73) | 11 | 59.4 (109) | 8 | 12.2 (27) | NS | 30 | 42.6 (81) | NS |
| 01:04:01 | 4 | 48.2 (96) | 7 | 171 (228) | 14 | 18.0 (49) | NS | 25 | 65.6 (142) | NS |
| 01:04:04 | 20 | 118 (248) | 19 | 118 (165) | 12 | 31.8 (59) | NS | 51 | 97.6 (188) | 0.038 |
| 0105N | 8 | 30.7 (32) | 5 | 67.4 (151) | 10 | 14.1 (42) | NS | 23 | 31.5 (75) | NS |
| 3′UTR SNPe | ||||||||||
| 3777 (c/c) | 12 | 81.8 (228) | 5 | 61.6 (107) | 13 | 6.5 (21) | NS | 30 | 45.8 (151) | NS |
| 3952 (a/a) | 27 | 86.7 (217) | 11 | 64.6 (134) | 27 | 39.1 (77) | NS | 65 | 64.0 (158) | NS |
| 14-bp (I/I) | 6 | 16.4 (36) | 7 | 97.7 (135) | 6 | 0.45 (1.1) | NS | 19 | 41.3 (92) | NS |
CSW, commercial sex worker; HIV-1, human immunodeficiency virus type 1; I, insertion,
N, number of participants; NS, nonsignificant; SD, standard deviation; SNP, single nucleotide polymorphism; UTR, untranslated region.
Data are mean (SD).
P-values for the comparison between all groups were calculated with one-way analysis of variance test.
P-values were calculated with Mann-Whitney U test.
Presence of the allele in the homozygous or heterozygous states.
P = 0.051 for the comparison between HIV-1-uninfected CSWs and HIV-1-infected CSWs, P = 0.153 for the comparison between HIV-1-uninfected CSWs and HIV-1-uninfected non-CSWs and P = 0.002 for the comparison between HIV-1-infected CSWs and HIV-1-uninfected non-CSWs as determined by Mann-Whitney U test.
Presence of the variants in the homozygous state.