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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Anesthesiology. 2011 Oct;115(4):836–843. doi: 10.1097/ALN.0b013e318221fcc9

Figure 1. Prazosin and Idazoxan Did Not Attenuate the Analgesic Effects of Perineural Dexmedetomidine Added to Ropivacaine.

Figure 1

Each rat received a pretreatment perineural injection followed by a second injection 10 min later. The duration of sensory blockade was measured by assessing paw withdrawal latency (PWL) to a heat stimulus every 30 min following the nerve block with a maximum response of 15 s. All of the groups containing dexmedetomidine plus ropivacaine had a longer duration of sensory blockade when compared with ropivacaine alone.

Groups are noted in the upper right by the “Pretreatment/Second Injection.”

∝ = 0.00833

* indicates a significant difference for all three DEX groups when compared with the Saline/Ropiv control group.

+ indicates Saline/DEX+Ropiv and Prazosin/DEX+Ropiv are each significantly different from the Saline/Ropiv control group.

# indicates Prazosin/DEX+Ropiv significantly differs from both Idazoxan/DEX+Ropiv and the Saline/Ropiv control group.

BL = baseline; DEX = dexmedetomidine; Ropiv = ropivacaine