Skip to main content
. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Anesthesiology. 2011 Oct;115(4):836–843. doi: 10.1097/ALN.0b013e318221fcc9

Figure 2. The Ih Blocker ZD 7288 Did Not Increase the Duration of Dexmedetomidine-Mediated Analgesia.

Figure 2

The duration of the sciatic nerve block was measured by paw withdrawal latency (PWL) to a thermal stimulus every 30 min. Both ZD 7288 and dexmedetomidine increased the duration of sensory blockade when compared with the Saline/Ropivacaine control group. There was no additive effect when both ZD 7288 and dexmedetomidine were coadministered with ropivacaine.

Groups are noted in the upper right by the “Pretreatment/Second Injection.”

∝ = 0.00833

* indicates the Saline/Ropiv control group is significantly different from the other three groups. At 150 min, there is also a significant difference between Saline/DEX+Ropiv and ZD 7288/Ropiv.

# indicates Saline/DEX+Ropiv and ZD 7288/Ropiv are each significantly different from the Saline/Ropiv control group.

BL = baseline; DEX = dexmedetomidine; Ropiv = ropivacaine