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. Author manuscript; available in PMC: 2012 Sep 29.
Published in final edited form as: J Phys Chem B. 2011 Sep 8;115(38):11254–11260. doi: 10.1021/jp2047807

Figure 4.

Figure 4

Free energy profiles for the formation of prereactive complex for wild-type BChE binding with (−)-cocaine (left), wild-type BChE binding with (+)-cocaine (middle), and the A328W/Y332G mutant binding with (−)-cocaine (right).