Table 1.

Pharmacogenomics in the renin-angiotensin system (RAS): Studies of blood pressure response to RAS blockade among genetic variants

Study	Year	Area	Ethnicity	Patients, N	Drug class	Drug	Genetic variant of the RAS	Significant difference?
Nordestgaard et al. [24••]	2010	Scandinavia	White (92%)	1,774	ARB	Losartan	ACE (I/D)	No
							AGT (M235T)	No
							AT1 (A1166C)	No
Konoshita et al. [25••]	2009	Japan	Japanese (100%)	231	ARB	Valsartan	ACE (I/D)	No
							AGT (M235T)	No
							AT1 (A1166C)	No
							AT2 (C3123A)	No
							REN (C-5312T)	Yes
Redon et al. [26]	2005	Spain	Spanish (100%)?	206	ARB	Telmisartan	ACE (I/D)	No
							AGT (A-6G)	No
							AT1 (A1166C,	No
							C573T)	No
Yu et al. [33]	2009	China	Chinese (100%)	509	ACEI	Imidapril or benazepril	AT1 (A1166C)	No
Filigheddu et al. [27]	2008	Italy (North Sardinia)	White (100%)	191	ACEI	Fosinopril	ACE (I/D)	No
							AGT (A-6G)	No
							AT1 (A1166C)	No
Fan et al. [43]	2007	China	Chinese (100%)	624	ACEI	Captopril	ACE2 (rs2106809)	Yes
Brunner et al. [34]	2007	USA	White (35%)	551	ACEI	Trandolapril	AT1 (A1166C)	No
			Hispanic (44%)
Su et al. [32]	2007	China (Shanghai)	Chinese (100%)	1,447	ACEI	Benazepril	AGT (multi loci)	Yes
							AT1 (multi loci)	Yes
							AT2 (multi loci)	No
Arnett et al. [28]	2005	USA	White (61%)	7,528	ACEI	Lisinopril	ACE (I/D)	No
			Black (35%)
Yu et al. [31]	2005	China	Chinese (100%)	501	ACEI	Imidapril or benazepril	AGT (M235T)	No
Yu et al. [29]	2003	China	Chinese (100%)	517	ACEI	Imidapril or benazepril	ACE (I/D)	No

ARB angiotensin receptor blocker; ACE angiotensin-converting enzyme, ACEI ACE inhibitor; ACE (I/D) insertion and deletion genetic variant of intron 16; AGT angiotensinogen; AT1 angiotensin II type 1 receptor; AT2 angiotensin II type 2 receptor; REN renin