Table 2.
Validated conditional GEMMs suitable for derivation of ESCs
| Tumor type | Conditional alleles | Cre induction | Reference |
|---|---|---|---|
| Hereditary breast cancer | Brca1F/F;Trp53F/F | K14-Cre or WAP-Cre | [18] |
| Lobular breast cancer | Cdh1F/F;Trp53F/F | K14-Cre | [15] |
| Small cell lung cancer | RbF/F ;Trp53F/F | Intratracheal Adeno-Cre | [19] |
| Non-small cell lung cancer | LSL-KrasG12D | Intratracheal Adeno-Cre | [44] |
| Mesothelioma | Nf2F/F;Trp53F/F;Ink4a-/- | Intrathoracic Adeno-Cre | [17] |
| Pancreatic cancer | LSL-KrasG12D LSL-Trp53R172H | Pdx-Cre | [45, 46] |
| Melanoma | LSL-BrafV600E;Ink4a-/- | Tyrosinase-CreERT2 | [47] |