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. Author manuscript; available in PMC: 2012 Sep 30.
Published in final edited form as: J Neurosci Methods. 2011 Jul 23;201(1):67–77. doi: 10.1016/j.jneumeth.2011.07.012

Figure 1.

Figure 1

DCHist method overview. A chronic single-shank, silicon MEA (a), along with an unmounted MEA (b) held by vacuum tweezers. (c) A magnified bright field view of a NeuroNexus MEA tip; circular iridium electrode sites and polysilicon tracings are visible. (d) A cortically-implanted, chronic MEA is shown during surgery, prior to covering the ribbon cable with protective silicone elastomer and dental acrylic. (e) Insertion of an unmounted MEA into rat motor cortex; a micromanipulator positioned vacuum tweezers which hold and release the MEA. (f) A soldering iron was used to expose the silicon elastomer; the chronic MEA ribbon cable (arrow) was then cut at the surface of the fixed brain. (g) A brain section with in situ microdevice (arrow) is shown, mounted within a two-sided slide after histological labeling. (h) In this image fluorescent chemical (Hoe342) and antibody (Iba1) labels were collected, along with laser reflectance outlining the microdevice surface and reflective components. (For interpretation of the references to color in this gure legend, the reader is referred to the web version of the article.)