TABLE 2.

Annotation Clustering of Genes Constitutively Induced or Suppressed with Nrf2 Activation Using DAVID Analysis

Term	Enrichment score	Gene symbols
Top annotation cluster for the set of genes induced through Nrf2 activation
Glutathione transferase and glutathione metabolism	8.2	Gstm1, Gss, Gsta2, Gstm2, Gsta3, Gstm3, Gclc, Gstm4, Gsta4, Gpx4, Gstm6
Oxidation reduction and NADPH bind enzymes	6.0	Cyp2g1, Xdh, Ptgr1, Htatip2, Ugdh, Coq7, Fth1, Akr1c13, Akr1a4, Cryl1, Fmo1, Gpx4, Aox1, Cyp2a5, Txnrd1, Nqo1, Srxn1
Carboxylesterase	3.9	Ces2, Ces1, BC015286, Ces5
Chemical and iron homeostasis	3.2	Xdh, Ftl1, Gclc, Fech, Ftl2, Hexa, Hexb, Bnip3, Afg3l2, Fth1, Abcg8, Anxa7
Cofactor biosynthetic process	2.4	Gss, Fech, Gclc, Coq7, Gch1
Top annotation cluster for the set of genes suppressed through Nrf2 activation
Response to nutrient and extracellular stimulus	2.3	Avpr1a, Adipor2, Cp, Apom, Cbs

Note. DAVID (http://david.abcc.ncifcrf.gov) database was used to identify the pathways enriched in genes constitutively induced or suppressed with Nrf2 activation. Pathway enrichment was determined by the enrichment score > 2.