. 2011 Jul 21;123(2):471–479. doi: 10.1093/toxsci/kfr187

TABLE 1.

Body Weights, SCGE Data, Generated Either in Neutral or Alkaline Environment and Either in the Presence (PK+) or in the Absence (PK–) of Proteinase K, and TBARS in the Mixed Cell Brain Population, and Apoptotic Neurons (TUNEL+) in the Brain Cortex of Mice Exposed to Varying Doses of MCS

Group	TPM	No. of	Body weight (g )			SCGE (TM)		SCGE (TM)		TBARS	TUNEL+
	(mg/m³)	mice	14 days	21 days	28 days	Neutral	Alkaline	PK–	PK+	(nmol/mgprotein)	neurons(%)
A	0	12	10.0 ± 0.26	13.1 ± 0.30	23.1 ± 0.63	5.4 ± 0.29	48.6 ± 2.02	31.9 ± 1.23	33.9 ± 1.63	0.5 ± 0.12	1.4 ± 0.51
B	119	10	12.3 ± 0.37	14.6 ± 0.38	25.4 ± 1.22	6.3 ± 0.40	67.8 ± 2.41^**	27.1 ± 1.62	41.6 ± 2.20^***	0.7 ± 0.11	1.6 ± 1.52
C	292	13	6.3 ± 0.35^**	9.3 ± 0.39^**	18.8 ± 0.42^**	12.1 ± 0.50^**	68.6 ± 2.48^**	38.3 ± 1.46	49.0 ± 1.86^{, **}	0.7 ± 0.15	2.0 ± 1.22
D	438	9	6.9 ± 0.31^**	10.2 ± 0.29^**	17.4 ± 0.50^**	15.6 ± 0.92^**	79.2 ± 2.84^**	59.7 ± 2.71^*	75.8 ± 2.61^{, *}	1.2 ± 0.16^*	3.2 ± 1.68
E^a	438	11	6.4 ± 0.28^**	9.7 ± 0.53^**	25.5 ± 1.06	NT	NT	28.5 ± 1.51	29.8 ± 2.27	NT	NT

Note. All data are means ± SE within each experimental group. NT, not tested. ^*p < 0.05 and ^**p < 0.001, as compared with the corresponding controls (dose 0 of TPM); ^***p < 0.001, as compared with the corresponding PK–.

^a The mice in this group were sacrificed one week after discontinuation of exposure to MCS rather than the day after.