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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Behav Brain Res. 2011 Aug 11;225(2):473–481. doi: 10.1016/j.bbr.2011.08.005

Figure 1.

Figure 1

The age-effect function of age of onset and nicotine self-administration averaged across sex, infusions (mean±sem) per 45-min. session for each of the four consecutive weeks of nicotine access as well as the week of nicotine access after one week of enforced abstinence. There was a significant Age-of-onset × Week-of-access interaction (p<0.05). Analysis of the simple main effects of age-of-onset during each week showed that during the first week of access the rats beginning access at four and five weeks of age self-administered significantly more nicotine than those beginning at seven or eight weeks of age (p<0.05-p<0.01). During the second week of access the rats beginning access at five weeks of age self-administered significantly more nicotine (p<0.05) than the rats that began access at eight weeks of age.