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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Behav Brain Res. 2011 Aug 11;225(2):473–481. doi: 10.1016/j.bbr.2011.08.005

Figure 8.

Figure 8

Six vs. eight-week old age of onset of nicotine self-administration effect on the relationship of later cocaine self-administration to estrus phase, infusions (mean±sem) per 45-min. session in female rats. The rats that had begun nicotine access at six weeks did not show any effect of estrus phase on subsequent cocaine self-administration. In contrast rats that had begun nicotine access at eight weeks of age did show a significantly (p<0.05-0.005) higher cocaine self-administration during the estrus phase than during the other phases of the cycle.