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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Neurobiol Aging. 2011 May 6;33(7):1215–1227. doi: 10.1016/j.neurobiolaging.2011.02.012

Table 2.

Study variables by biomarkers (high/ low) and HTN (absent/ present) groups. Values are presented as mean ± standard deviation. For t-tau the cut-off of 350 pg/mL (Hansson et al., 2006) was used, for p-tau231 the cutoff of 18 pg/mL (Buerger et al., 2003), for Aβ42/Aβ40 the cut-off of .11 (Lewczuk et al., 2004). High and low p-tau231/Aβ42 and t-tau/Aβ42 groups were defined based on the median split. For GM comparisons p values are given for F tests, corrected for age, gender and education. For WMH comparisons p values are given for F tests corrected for age and gender; the number of subjects with WMH information available n=112. For MTL GM comparisons p values are given for t tests, as explained in the text.

Age
(years)		 Female
(%)		 Education
(years)		 HTN
(%)		 GM volume
(% ICV)		 WMH MTL GM
t-tau Low n=80 60.7±8.9 64 16.7 ± 2.0 31 47 ± 2 1.12 ± 1.08 .80 ± .05
High n=35 67.1±9.4 57 17.1 ± 2.1 40 46 ± 3 1.13 ± 1.26 .78 ± .05
p .001 ns ns ns ns ns .05
p-tau231 Low n=91 61.0± 8.9 66 16.7 ± 1.9 33 47 ± 2 .98 ± 1.04 .80 ± .05
High n=24 68.7± 9.3 46 17.5 ± 2.4 37 46 ± 2 1.75 ± 1.29 .78 ± .05
p .001 .07 .02 ns .10 ns ns
Aβ42/Aβ40a High n=48 60.6 ± 7.0 65 16.8 ± 1.9 33 47 ± 2 .91 ± .97 .79 ± .05
Low n=38 63.8±11.0 53 16.6 ± 2.0 31 47 ± 2 1.26 ± 1.20 .79 ± .05
p ns ns ns ns ns ns ns
t-tau/Aβ42a Low n=43 60.2±7.3 58 16.7 ± 2.0 33 48 ± 2 .78 ± .90 .79 ± .05
High n=43 63.8±10.3 60 16.7 ± 1.9 33 47 ± 2 1.35 ± 1.19 .79 ± .05
p .07 ns ns ns .07 ns ns
p-tau/Aβ42a Low n=43 60.2±7.4 63 16.5 ± 2.0 30 48 ± 2 1.05 ± 1.06 .80 ± .05
High n=43 64.0±10.2 56 16.9 ± 1.9 35 46 ± 2 1.10 ± 1.13 .79 ± .05
p .04 ns ns ns .005 ns ns
HTN Absent n=76 60.5 ± 9.1 72 16.7 ± 2.1 NA 47 ± 2 .81 ± .86 .80 ± .05
Present n=39 66.7±8.9 41 17.2 ± 1.9 NA 46 ± 2 1.80 ±1.32 .78 ± .05
p .001 .001 ns NA .06 .001 .02
a

results presented for 86 subjects and for WMH for 85 subjects.

HTN: hypertension, GM: gray matter, WMH: white matter hyperintensity score expressed as a sum of Fazekas scores for deep and periventricular white matter hyperintensities.

MTL GM: Medial temporal lobe gray matter, the values represents estimates (densities) extracted from processed GM images using MTL ROI (Li et al., 2008).