Table 3.
Study variables by biomarker-HTN groups. Values are presented as mean ± standard deviation. For GM volume comparisons p values are given for F tests, corrected for age, gender and education. For WMH comparisons p values are given for F tests corrected for age and gender; the number of subjects with WMH information available n=112. For MTL GM comparisons p values are given for F tests not corrected, as explained in the text.
B−/H−: normal biomarker level and HTN absent
B−/H+: normal biomarker level and HTN present
B+/H−: abnormal biomarker level and HTN absent
B+/H+: abnormal biomarker level and HTN present.
| Age | Female (%) |
Education (years) |
GM volume (% ICV) |
WMH | MTL GM | ||
|---|---|---|---|---|---|---|---|
| t-tau-HTN | B−/H− n=55 | 58.3± 7.5 | 75 | 16.6 ± 2.0 | 48 ± 2 | .75 ± .81 | .80 ± .05 |
| B−/H+ n=25 | 65.9±9.6 | 40 | 17.1 ± 2.0 | 46 ± 2 | 1.90 ± 1.20 | .79 ± .04 | |
| B+/H− n=21 | 66.4±10.5 | 66 | 16.9 ± 2.3 | 47 ± 3 | .95 ± .97 | .79 ± .05 | |
| B+/H+ n=14 | 68.1±7.7 | 43 | 17.4 ± 1.9 | 46 ± 3 | 1.64 ± 1.55 | .77 ± .06 | |
| p | <.001 | .01 | ns | ns | .003 | .04 | |
| p-tau231-HTN | B−/H− n=61 | 58.9±7.8 | 77 | 16.6 ± 1.9 | 48 ± 2 | .74 ± .81 | .80 ± .05 |
| B−/H+ n=30 | 65.3±9.6 | 43 | 16.7 ± 1.9 | 46 ± 2 | 1.47 ± 1.28 | .78 ± .04 | |
| B+/H− n=15 | 67.2±11.3 | 53 | 16.8 ± 2.7 | 46 ± 2 | 1.07 ±1.03 | .79 ± .06 | |
| B+/H+ n=9 | 71.3±4.1 | 33 | 18.8 ± 0.9 | 46 ± 2 | 2.89 ±.78 | .77 ± .05 | |
| p | <.001 | .003 | .01 | .04 | .001 | .07 | |
| Aβ42/Aβ40-HTNa | B−/H− n=32 | 58.0±6.0 | 78 | 16.5 ± 1.8 | 48 ± 2 | .61 ± .62 | .80 ± .04 |
| B−/H+ n=16 | 66.0±5.8 | 37 | 17.4 ± 2.1 | 46 ± 3 | 1.50 ± 1.26 | .78 ± .05 | |
| B+/H− n=26 | 63.3±11.2 | 58 | 16.5 ± 2.2 | 47± 2 | 1.04 ± 1.04 | .80 ± .05 | |
| B+/H+ n=12 | 64.7±10.7 | 42 | 16.7 ± 1.6 | 47 ± 3 | 1.75 ± 1.42 | .77 ± .04 | |
| p | .009 | .02 | ns | ns | .06 | ns | |
| t-tau/Aβ42-HTNa | B−/H− n=29 | 58.0±6.4 | 72 | 16.3 ± 2.0 | 48 ± 2 | .71 ± .76 | .80 ± .05 |
| B−/H+ n=14 | 64.9±7.0 | 29 | 17.5 ± 1.9 | 46 ± 3 | 1.71 ± 1.27 | .78 ± .04 | |
| B+/H− n=29 | 62.7±10.7 | 66 | 16.7 ± 2.0 | 47± 2 | .89 ± .94 | .80 ± .05 | |
| B+/H+ n=14 | 66.0±9.0 | 50 | 16.7 ± 1.8 | 47 ± 2 | 1.50 ± 1.40 | .77 ± .05 | |
| p | .02 | .04 | ns | ns | .06 | ns | |
| p-tau/Aβ42-HTNa | B−/H− n=30 | 57.9±6.5 | 70 | 16.3 ± 1.9 | 48 ± 2 | .55 ± .57 | .80 ± .05 |
| B−/H+ n=13 | 64.9±7.1 | 46 | 17.0 ± 2.2 | 47 ± 3 | 1.30 ± 1.25 | .78 ± .05 | |
| B+/H− n=28 | 63.0±10.7 | 68 | 16.7 ± 2.1 | 47± 2 | 1.07 ± 1.01 | .80 ± .05 | |
| B+/H+ n=15 | 65.9±9.2 | 33 | 17.2 ± 1.6 | 46 ± 2 | 1.87 ± 1.36 | .77 ± .04 | |
| p | .01 | .06 | ns | .02 | .03 | ns | |
results presented for 86 subjects and for WMH for 85 subjects.
HTN: hypertension, GM: gray matter, WMH: white matter hyperintensity score expressed as a sum of Fazekas scores for deep and periventricular white matter hyperintensities.
MTL GM: Medial temporal lobe gray matter, the values represents estimates (densities) extracted from processed GM images using MTL ROI (Li et al., 2008).