Table 4.
SPM analysis. Regions showing significant differences between groups with high and low biomarkers levels. For t-tau the cut-off of 350 pg/mL (Hansson et al., 2006) was used, for p-tau231 the cutoff of 18 pg/mL (Buerger et al., 2003), for Aβ42/Aβ40 the cut-off of .11 (Lewczuk et al., 2004). High and low t-tau/Aβ42 and p-tau231/Aβ42 groups were defined based on the median split. All analyses accounted for age, gender and education.
| Cluster extent |
Brain region | Talaraich coordinates x,y,z |
F value |
|
|---|---|---|---|---|
| t-tau+ < t-tau− | 75 | R Hippocampus | 30, −12, −24 | 3.52 |
| 131 | L Parietal Lobe, Precuneus, BA 7 | −9, −64, 45 | 4.16 | |
| 112 | L Insula, BA 13 | −26, −30, 14 | 4.37 | |
| 105 | L Anterior Cingulate, BA 24 | 0, −13, 40 | 3.82 | |
| p-tau231+ < p-tau231− | 317 | R Limbic Lobe, BA 28 | 29, −10, −25 | 3.84 |
| R Inferior Temporal Gyrus, BA 20 | 33, 0, −32 | 3.54 | ||
| 75 | L Inferior Temporal Gyrus, BA 20 | −50, −10, −20 | 3.84 | |
| Aβ42/Aβ40- < Aβ42/Aβ40+a | 108 | L Midbrain | −6, −23, −4 | 3.59 |
| t-tau/Aβ42+ < t-tau/Aβ42−a | 86 | R Superior Parietal Lobule, BA 7 | 11, −61, 53 | 3.95 |
| 94 | L Middle Temporal Gyrus, BA 21 | 71, −30, −4 | 4.02 | |
| 85 | L Anterior Cingulate, BA 32 | −14, 15, 34 | 3.77 | |
| p-tau231/Aβ42+ < p-tau231/Aβ42−a | 166 | R Middle Temporal Gyrus, BA 21 | 53, 10, −31 | 4.51 |
| 96 | L Middle Temporal Gyrus, BA 21 | −35, −4, −25 | 3.58 | |
| HTN+ < HTN− | 447 | R Cerebellum, Posterior Lobe | 53, −60, −30 | 4.32 |
| 83 | R Superior Frontal Gyrus, BA 9 | 15, 57, 30 | 4.26 | |
| 142 | R Cerebellum, Anterior Lobe | 12, −29, −15 | 4.17 | |
| 88 | R Inferior Frontal Gyrus, BA 44 | 57, 7, 19 | 4.15 | |
| 2435 | L Cerebellum, Posterior Lobe | −27, −61, −21 | 4.46 | |
| 131 | L Lingual Gyrus, BA 19 | −30, −61, −4 | 3.66 |
results presented for 86 subjects.
p <.001, minimal cluster size=75
t-tau+: high t-tau group; t-tau-: low t-tau group,
p-tau231+: high p-tau231 group; p-tau231-: low p-tau231 group,
Aβ42/Aβ40+: high Aβ42/Aβ40 group; Aβ42/Aβ40-: low Aβ42/Aβ40 group
t-tau/Aβ42+: high t-tau/Aβ42 group; t-tau/Aβ42-: low t-tau/Aβ42 group
p- tau231/Aβ42+: high p-tau231/Aβ42 group; p-tau231/Aβ42-: low p-tau231/Aβ42 group
HTN+: group with hypertension, HTN-: group without hypertension
BA: Brodman area