Table 5.
SPM analysis. Regions showing regions of significant correlations between CSF AD biomarkers and gray matter density. All correlations were negative except for these presented for Aβ42/Aβ40, which were positive. All analyses accounted for age, gender and education.
| Clust er extent |
Brain region | Talaraich coordinates x,y,z |
F value |
|
|---|---|---|---|---|
| t-tau | 2349 | R Parietal Lobe, Precuneus, BA 7 | 8, −65, 48 | 5.31 |
| L Parietal Lobe, Precuneus, BA 7 | −8, −64, 44 | 4.92 | ||
| 230 | L Insula, BA 13 | −26, −31, 14 | 4.84 | |
| 611 | R Caudate Tail | 36, −34, 2 | 4.18 | |
| R Thalamus | 27, −31, 9 | 3.84 | ||
| 92 | R Inferior Temporal Gyrus, BA 20 | 47, −18, −24 | 3.70 | |
| p-tau231 | 1788 | R Superior Temporal Gyrus, BA 38 | 30, 8, −26 | 5.56 |
| R Superior Temporal Gyrus, BA 38 | 39, 1, −15 | 5.01 | ||
| R Limbic Lobe, BA 36 | 23, −4, −30 | 4.39 | ||
| R Limbic Lobe, BA 28 | 29, −10, −25 | 4.02 | ||
| 201 | R Inferior Temporal Gyrus, BA 20 | 47, −19, −27 | 4.13 | |
| 163 | L Parietal Lobe, Precuneus, BA 7 | −26, −69, 28 | 4.12 | |
| 249 | R Inferior Parietal Lobule, BA 40 | 36, −49, 55 | 3.99 | |
| 151 | L Inferior Temporal Gyrus, BA 20 | −51, −9, −20 | 3.87 | |
| 151 | R Thalamus | 3, −19, 15 | 3.70 | |
| 91 | L Amygdala | −30, −4, −24 | 3.62 | |
| Aβ42/Aβ40a | 685 | L Thalamus | −6, −22, −1 | 4.37 |
| R Thalamus | 8, −17, 1 | 3.75 | ||
| L Midbrain | −3, −15, −6 | 3.70 | ||
| 386 | L Thalamus | −11, −28, 14 | 4.26 | |
| 293 | R Thalamus | 12, −29, 12 | 3.98 | |
| R Caudate | 15, −8, 17 | 3.53 | ||
| 121 | L Insula, BA 13 | −41, 17, 2 | 3.87 | |
| 77 | L Lentiform Nucleus | −20, 0, 7 | 3.73 | |
| t-tau/Aβ42a | None | |||
| p-tau231/Aβ42a | 111 | L Superior Temporal Gyrus, BA 38 | −54, 5, −8 | 5.52 |
| 157 | R Temporal Lobe, BA 21 | 41, −3, −12 | 4.53 | |
| 102 | R Superior Temporal Gyrus, BA 38 | 30, 9, −27 | 4.10 | |
| 94 | R Middle Temporal Gyrus, BA 21 | 64, −24, −6 | 3.68 |
a
results presented for 86 subjects.
p <.001, minimal cluster size=75
BA: Brodman area