TASK-3 knock-outs show increased amplitude in sleep EEG architecture. Baseline ECoG/EMG of Wildtype (closed symbols, n=5) and TASK-3 homozygous mutant (open symbols, n=4) mice was monitored continuously over 16 days, and scored for both mean time spent in Active Wake, Delta and REM sleep (upper panel) as well as the number of entries into these sleep stages during 30 minute intervals. Each value is the 16 day mean ± SEM plotted on a single 24 hour period. Time points exhibiting significant differences from wildtype are highlighted by grey lines with short, medium and long tics marks representing p values ≤ 0.05, 0.01, ≤ 0.001 (linear mixed effects model for repeated measures).