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Model for the translation of the mutant IκBα allele E 14 X. a: N-terminal sequence of the IKBA cDNA and likelihood scores for the use of different TIS in the WT and the mutated allele. b: Proposed model for the translation of the δN-IκBα protein. The proximity of the new stop codon induced by the nonsense mutation to a second in-frame methionine residue would allow the translation of the majority of the IκBα ORF by a reinitiation of translation mechanism.
