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. Author manuscript; available in PMC: 2011 Sep 25.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Dec 5;20(3):1241–1246. doi: 10.1016/j.bmcl.2009.11.123

Scheme 3.

Scheme 3

Reagents and conditions: (a) 8a, Li(ClO4), Et2O; (b) CF3CO2H, CH2Cl2; (c) 11a or, 11b, Et3N, CH2Cl2; (d) N-methylmorpholine, iso-butylchloroformate, 8b–d, THF; (e) CF3CO2H, CH2Cl2, then 11b, Et3N, CH2Cl2.