. Author manuscript; available in PMC: 2012 Sep 21.

Published in final edited form as: J Am Chem Soc. 2011 Jul 27;133(37):14476–14479. doi: 10.1021/ja203172c

Table 2.

Comparison of metabolic stabilities measured with the MesaPlate and with chromatography

Isoform	Substrate	Conc. (μM)	MesaPlate	Chromatography
Isoform	Substrate	Conc. (μM)	−r_RH^a	−r_RH^a
CYP2D6	Amitriptyline	60	6.7 ± 0.8	3.8 ± 0.4
CYP2D6	Metoprolol	100	12.2 ± 2.2	9.8 ± 2.3
CYP1A2	3-methylindole	500	15.8 ± 1.8	10.7 ± 0.8
CYP1A2	lidocaine	300	9.9 ± 0.6	9.7 ± 1.2

nmol/min/nmol P450